反应详情

A solution of 7.95 g of 5-(benzyloxy)-2-(methoxycarbonyl)-1-tetralone in 80 ml of methanol was ice-cooled and 0.97 g of sodium borohydride was added in five portions. After stirring for 30 minutes, an ice bath was removed and the mixture was further stirred for 30 minutes. The reaction solution was diluted with iced water, extracted with diethyl ether, washed with water and dried over anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressured. The residue was purified by silica gel column chromatography to obtain 5.96 g of the desired compound as a colorless oily substance.

1. temperaturecooled
2. customan ice bath was removed
3. stirringthe mixture was further stirred for 30 minutes
4. additionThe reaction solution was diluted with iced water
5. extractionextracted with diethyl ether
6. washwashed with water
7. dry with materialdried over anhydrous magnesium sulfate
8. customthe solvent was evaporated under reduced pressured
9. customThe residue was purified by silica gel column chromatography