5-Chloro-2,3-Diphenylpyrazine → 4-((5,6-Diphenyl-Pyrazin-2-yl)(isopropyl)amino)butan-1-ol

Participants

Reaction Conditions

Reaction Steps

30 g of 2-chloro-5,6-diphenylpyrazine and 131.22 g of 4-(isopropylamino)-1-butanol were mixed and then heated with stirring at 190° C. for 10 hours. The reaction solution was air-cooled, poured into water, extracted with diethyl ether, dried over anhydrous magnesium sulfate and then concentrated. The residue was purified by silica gel column chromatography to obtain 22.96 g of the desired compound as a colorless crystal having a melting point of 102 to 103° C.

Provenance & Evidence