5-Chloro-2,3-Diphenylpyrazine → HCID 18452652, compound

HRID 1271278Notes

Reaction equation

HRID 1271278 reaction equation
Cl[C:2]1[CH:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:3]=1.[Si:20]([O:27][CH2:28][CH2:29][CH:30]1[CH2:35][CH2:34][CH2:33][NH:32][CH2:31]1)([C:23]([CH3:26])([CH3:25])[CH3:24])([CH3:22])[CH3:21]>>[Si:20]([O:27][CH2:28][CH2:29][CH:30]1[CH2:35][CH2:34][CH2:33][N:32]([C:2]2[CH:7]=[N:6][C:5]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)=[C:4]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:3]=2)[CH2:31]1)([C:23]([CH3:25])([CH3:26])[CH3:24])([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 36544935-Chloro-2,3-DiphenylpyrazineHCID 100374403-(2-{[tert-Butyl(dimethyl)silyl]oxy}ethyl)piperidine

Product 1

HCID 18452652HCID 18452652, compound

Procedure

In the same manner as in the step 1 of Example 9, except that 2-chloro-5,6-diphenylpyrazine was used in place of 2-chloro-5,6-di-p-tolylpyrazine and (±)-3-[2-(tert-butyldimethylsilyloxy)ethyl]piperidine was used in place of 4-(methylamino)-1-butanol, the desired compound was prepared.

Sources & evidence

ORD record
ord-10ba22c7ec0d4941900d8b8de7191470
Source dataset
uspto-grants-2007_04
Patent number
US07205302B2

Reaction notes

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