Phenylephrine → HCID 69354999, compound

HRID 1271280Notes

Reaction equation

Cl[C:2]1[CH:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:3]=1.[CH3:20][NH:21][CH2:22][C@H:23]([OH:31])[C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([OH:30])[CH:25]=1>>[C:8]1([C:5]2[N:6]=[CH:7][C:2]([N:21]([CH2:22][C@@H:23]([C:24]3[CH:25]=[C:26]([OH:30])[CH:27]=[CH:28][CH:29]=3)[OH:31])[CH3:20])=[N:3][C:4]=2[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 6041Phenylephrine

HCID 36544935-Chloro-2,3-Diphenylpyrazine

Product 1

HCID 69354999HCID 69354999, compound

Procedure

In the same manner as in the step 1 of Example 9, except that 2-chloro-5,6-diphenylpyrazine was used in place of 2-chloro-5,6-di-p-tolylpyrazine and L-phenylephrine was used in place of 4-(methylamino)-1-butanol, the desired compound was prepared as a pale brown amorphous.

Sources & evidence

ORD record: ord-41baff80ad45489b86d3774a6595ec65
Source dataset: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07205302B2

Reaction notes

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