5-Chloro-2,3-Diphenylpyrazine → 1-(benzyloxy)-3-{2-[N-(5,6-diphenylpyrazin-2-yl)-N-methylamino]ethyl}benzene

HRID 1271284Notes

Reaction equation

HRID 1271284 reaction equation
Cl[C:2]1[CH:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:3]=1.[CH2:20]([O:27][C:28]1[CH:29]=[C:30]([CH2:34][CH2:35][NH:36][CH3:37])[CH:31]=[CH:32][CH:33]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH2:20]([O:27][C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([CH2:34][CH2:35][N:36]([C:2]2[CH:7]=[N:6][C:5]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)=[C:4]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:3]=2)[CH3:37])[CH:29]=1)[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 36544935-Chloro-2,3-DiphenylpyrazineHCID 22931944N-Methyl-3-(benzyloxy)-benzeneethanamine

Product 1

HCID 229319581-(benzyloxy)-3-{2-[N-(5,6-diphenylpyrazin-2-yl)-N-methylamino]ethyl}benzene

Procedure

In the same manner as in the step 1 of Example 9, except that 2-chloro-5,6-diphenylpyrazine was used in place of 2-chloro-5,6-di-p-tolylpyrazine and 1-[3-(benzyloxy)phenyl]-2-(methylamino)ethane was used in place of 4-(methylamino)-1-butanol, the desired compound was prepared as a pale yellow crystal having a melting point of 78 to 78.5° C.

Sources & evidence

ORD record
ord-f4546d9a95c344518451e4d198aaa8f2
Source dataset
uspto-grants-2007_04
Patent number
US07205302B2

Reaction notes

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