Sodium Hydroxide → HCID 69354532, compound

Participants

Reaction Steps

While stirring under ice cooling, to a solution of 350 mg of 2-{4-[(5,6-diphenylpyrazin-2-yl)thio]butyloxy}acetic acid tert-butyl ester obtained in Example 34 in 5 ml of chloroform, 191 mg of 70% m-chloroperoxybenzoic acid was added, followed by stirring for 2 hours. The reaction solution was combined with 20 ml of a 0.2N sodium hydroxide solution, extracted with chloroform and dried over anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to obtain 145 mg of the desired compound as a pale yellow oily substance.

Provenance & Evidence