反应详情

2-Bromo-1,1-dimethoxyethane (0.1 mole) and 1,3-butanediol (0.1 mole) are charged into a glass reaction vessel fitted with a mechanical stirrer, thermometer, Dean Stark trap and reflux condenser. Toluene sulfonic acid (0.1 grams) is added and the reaction mixture is heated and alcohol removed. When alcohol evolution ceases, the reaction mixture is then cooled to room temperature, treated with sodium carbonate (5 grams) and filtered. Volatiles are stripped from the filtrate using a rotary evaporator to yield the desired product 2-bromomethyl-4-methyl-1,3-dioxane as the residue.

1. customfitted with a mechanical stirrer
2. temperaturethermometer, Dean Stark trap and reflux condenser
3. temperaturethe reaction mixture is heated
4. customalcohol removed
5. additiontreated with sodium carbonate (5 grams)
6. filtrationfiltered
7. customa rotary evaporator