5-(N,N-Dimethylaminosulfonyl)-1,3,4-thiadiazol-2-yl isocyanate → N-[5-(N,N-dimethylaminosulfonyl)-1,3,4-thiadiazol-2-yl]-N'-(4-methyl-1,3-dioxan-2-ylmethyl)-N'-methylurea

Participants

Reaction Steps

N-(4-methyl-1,3-dioxan-2-ylmethyl)-methylamine (6 grams), 5-(N,N-dimethylaminosulfonyl)-1,3,4-thiadiazol-2-yl isocyanate dimer (6 grams) and chloroform (20 ml) were charged into a glass reaction vessel and stirred at room temperature for a period of about 2 hours. The solvent was then stripped off on a rotary evaporator and the residue treated with a mixture of diethyl ethyl (100 ml)/water (50 ml). The ether, layer was isolated and dried. Ether was stripped off an a rotary evaporator to yield the desired product N-[5-(N,N-dimethylaminosulfonyl)-1,3,4-thiadiazol-2-yl]-N'-(4-methyl-1,3-dioxan-2-ylmethyl)-N'-methylurea as the residue. Melting point 131° C.-133° C.

Provenance & Evidence