m-Toluidine → N-(3-Methoxy-4-oxazol-5-yl-phenyl)-N''-m-tolyl-malonamide

HRID 1271371Notes

Reaction equation

HRID 1271371 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:14][C:15](=[O:20])[CH2:16][C:17]([OH:19])=O)[CH:6]=[CH:7][C:8]=1[C:9]1[O:13][CH:12]=[N:11][CH:10]=1.[NH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[CH:23]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:14][C:15](=[O:20])[CH2:16][C:17]([NH:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[CH:23]=2)=[O:19])[CH:6]=[CH:7][C:8]=1[C:9]1[O:13][CH:12]=[N:11][CH:10]=1

Participants

3

Reactant 2

HCID 7934m-ToluidineHCID 220584973-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-3-oxopropanoic acid

Product 1

HCID 10361468N-(3-Methoxy-4-oxazol-5-yl-phenyl)-N''-m-tolyl-malonamide

Procedure

56 was prepared from 56A by a route analogous to that used for the preparation of 5, replacing aniline with m-toluidine. LC/MS: ret. timeA=3.783 min., MS (M+H)+=366.

Workup

  1. customthat used for the preparation of 5
  2. customtimeA=3.783 min., MS (M+H)+=366

Sources & evidence

ORD record
ord-53e28b5b9c434adc8a5fe11cbe2481d8
Source dataset
uspto-grants-2007_04
Patent number
US07205324B2

Reaction notes

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