Potassium Iodide → HCID 69475176, compound

Participants

Reaction Steps

0.264 g (1.00 mmol) 2-(2-Benzo[1,3]dioxol-5-yl-vinyl)-4-chloromethyl-oxazole, 0.217 g 1.00 mmol) 4-(4-[1,2,3]Triazol-1-yl-butyl)-phenol, 0.166 g (1.00 mmol) potassium iodide and 0.191 ml (1.00 mmol) of a 30% sodium methylate solution were added to 50.0 ml methanol and heated to reflux for 8 h. After removal of solvent, partitioning of the residue between 50 ml ethyl acetate and 15 ml water, the organic phase was washed with 10 ml water, 10 ml 0.1 N NaOH, 15 ml water twice and dried over sodium sulphate. The solution was concentrated to a volume until crystallisation of the product started. After leaving for 1 h at room temperature the precipitate was filtered, washed with diethyl ether and dried at 40° C. in vacuo. Yield 0.17 g (38%) 4.

Provenance & Evidence