Dimethylformamide → HCID 69476616, compound

Participants

Reaction Steps

To a solution of 0.217 g (1.00 mmol) 4-(4-[1,2,3]Triazol-1-yl-butyl)-phenol in 4 ml N,N-dimethyl formamide 40 mg (1.00 mmol) of NaH (60% dispersion in mineral oil) were added and the mixture stirred for 15 min at room temperature. Subsequently 0.3 g (1.00 mmol) 4-chloromethyl-2-[2-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-vinyl]-oxazole were added and stirring continued for 12 h. 20 ml of water were added, the resulting precipitate collected, washed with water (2×), methanol/water (1:1), ether (3×) and dried in vacuo yielding 0.42 g (87%) 1-[4-(4-{2-[2-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-vinyl]-oxazol-4-ylmethoxy}-phenyl)-butyl]-1H-[1,2,3]triazole as white solid.

Provenance & Evidence