Diethyl Ether → 1-[4-(4-{2-[2-(4-Trifluoromethoxy-phenyl)-vinyl]-oxazol-4-ylmethoxy}-phenyl)-butyl]-1H-[1,2,3]triazolium methanesulfonat

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Reaction Steps

12.1 g (25 mmol) 1-[4-(4-{2-[2-(4-Trifluoromethoxy-phenyl)-vinyl]-oxazol-4-ylmethoxy}-phenyl)-butyl]-1H-[1,2,3]triazole were dissolved in 150 ml tetrahydrofuran at 50° C., cooled to room temperature, treated with 1.625 ml (25 mmol) methanesulfonic acid and stirred for lh. After the addition of 300 ml diethyl ether stirring was continued for 1 h, the precipitate collected and washed with diethyl ether. Drying over phosphorus pentoxide yielded 12.4 g (85%) 1-[4-(4-{2-[2-(4-Trifluoromethoxy-phenyl)-vinyl]-oxazol-4-ylmethoxy}-phenyl)-butyl]-1H-[1,2,3]triazolium methanesulfonat.

Provenance & Evidence