HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1271405Generated: November 2, 2026
2-Pyridinecarboxaldehyde → 5-Chloro-3-[(pyridin-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one
https://huagongshe.com/reaction/1271405
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Pyridinecarboxaldehyde | HCID 14273 | — |
| Reactant | 5-Chlorooxindole | HCID 152801 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Chloro-3-[(pyridin-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one | HCID 69491172 | — |
Reaction Steps
A 5 mL of ethanol solution containing 5-chlorooxindole (167 mg, 1 mmol), 2-pyridine-carboxaldehyde (129 mg, 1.2 mmol) and 3 drops of piperidine was stirred at 80° C. for 6 hours. After cooling the solution to 5° C., yellow precipitate was obtained (200 mg, 78%). MS: m/z 257 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07205328B2 |
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| Source dataset | uspto-grants-2007_04 |
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| ORD ID | ord-b836a762aa1b4b55aeb7ccfbfc2f421b |
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| Source note | uspto-grants-2007_04 |
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