4-Nitrophenol → 1-(3-Chloropropoxy)-4-nitrobenzene

Participants

Reaction Steps

4-Nitrophenol (69.56 g, 0.5 mol), potassium carbonate (138.21 g, 1 mol) and 1-bromo-3-chloro propane (236.16 g, 1.5 mol) are refluxed in methyl ethyl ketone (800 ml) for 24 h. After filtration solvents are removed, the residue dissolved in ethyl acetate (1000 ml) and washed with NaOH (1M, 150 ml) and water (2×200 ml). Drying over sodium sulfate and concentration in vacuo yields 1-(3-Chloro-propoxy)-4-nitro-benzene as a yellow liquid.

Provenance & Evidence