反应详情

温度

120 °C

1-(3-Chloro-propoxy)-4-nitro-benzene (7 g, 32.5 mmol) is dissolved in 2-methyl-2-butanol (35 ml) followed by the addition of 1H-1,2,3-triazole (3.43 g, 48.7 mmol), potassium iodide (0.54 g, 3.25 mmol) and sodium hydroxide (1.95 g, 48.7 mmol). The mixture is stirred for 20 h at 120° C., evaporated to dryness and suspended in toluene. Washing with water, drying over sodium sulfate and concentration in vacuo yields a crude product, which is washed with ether yielding 1-[3-(4-nitro-phenoxy)-propyl]-1H-[1,2,3]triazole as a colorless solid. Yield 6 g (75%)

1. customevaporated to dryness
2. washWashing with water
3. dry with materialdrying over sodium sulfate and concentration in vacuo
4. customyields a crude product, which
5. washis washed with ether