反应详情

3-(4-Fluoro-2-trifluoromethyl-phenyl)-acrylamide (1.0 g, 4.29 mmol), dichloro acetone (2.18 g, 17.15 mmol) and toluene (10 ml) were kept at reflux temperature for 16 h with continuous removal of water by use of a Dean-Stark trap. After removal of solvents in vacuo, the residue was purified by chromatography on silica gel (eluent: heptane/ethyl acetate 2:1) yielding 0.93 g (71%) 4-chloromethyl-2-[2-(4-fluoro-2-trifluoromethyl-phenyl)-vinyl]-oxazole as tan solid.

1. temperatureat reflux temperature for 16 h
2. customwith continuous removal of water by use of a Dean-Stark trap
3. customAfter removal of solvents in vacuo
4. customthe residue was purified by chromatography on silica gel (eluent: heptane/ethyl acetate 2:1)