反应详情

3-(3-Trifluoromethoxy-phenyl)-acrylamide (0.99 g, 4.27 mmol), dichloro acetone (1.90 g, 14.95 mmol) and toluene (8 ml) were kept at reflux temperature for 16 h with continuous removal of water by use of a Dean-Stark trap. After removal of solvents in vacuo, the residue was purified by chromatography on silica gel (eluent: heptane/ethyl acetate 2:1) yielding 0.76 g (71%) 4-chloromethyl-2-[2-(3-trifluoromethoxy-phenyl)-vinyl]-oxazole as tan solid.

1. temperatureat reflux temperature for 16 h
2. customwith continuous removal of water by use of a Dean-Stark trap
3. customAfter removal of solvents in vacuo
4. customthe residue was purified by chromatography on silica gel (eluent: heptane/ethyl acetate 2:1)