4-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidine-1-carbonyl chloride → HCID 11465683, compound

HRID 1271498Notes

Reaction equation

HRID 1271498 reaction equation
[NH2:1][C@@H:2]1[CH2:8][CH2:7][CH2:6][CH2:5][N:4]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:3]1=[O:16].[O:17]=[C:18]1[N:27]([CH:28]2[CH2:33][CH2:32][N:31]([C:34](Cl)=[O:35])[CH2:30][CH2:29]2)[CH2:26][C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[NH:19]1>>[CH2:9]([N:4]1[CH2:5][CH2:6][CH2:7][CH2:8][C@@H:2]([NH:1][C:34]([N:31]2[CH2:32][CH2:33][CH:28]([N:27]3[CH2:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[NH:19][C:18]3=[O:17])[CH2:29][CH2:30]2)=[O:35])[C:3]1=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 183211084-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidine-1-carbonyl chlorideHCID 53487973(R)-3-Amino-hexahydro-1-(phenylmethyl)-2H-azepin-2-one

Product 1

HCID 11465683HCID 11465683, compound

Procedure

The title compound was prepared with (3R)-3-amino-1-benzylazepan-2-one and 4-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidine-1-carbonyl chloride using a similar procedure to Example 16. MS 476.2645 (M+1).

Sources & evidence

ORD record
ord-982beae2d0ec4167b023979f352beb62
Source dataset
uspto-grants-2007_04
Patent number
US07205292B2

Reaction notes

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