4-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidine-1-carbonyl chloride → HCID 11214031, compound

HRID 1271500Notes

Reaction equation

HRID 1271500 reaction equation
[NH2:1][C@@H:2]1[CH2:8][CH2:7][CH2:6][CH2:5][N:4]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([OH:16])[CH:11]=2)[C:3]1=[O:17].[O:18]=[C:19]1[N:28]([CH:29]2[CH2:34][CH2:33][N:32]([C:35](Cl)=[O:36])[CH2:31][CH2:30]2)[CH2:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[NH:20]1>>[OH:16][C:12]1[CH:11]=[C:10]([CH:15]=[CH:14][CH:13]=1)[CH2:9][N:4]1[CH2:5][CH2:6][CH2:7][CH2:8][C@@H:2]([NH:1][C:35]([N:32]2[CH2:33][CH2:34][CH:29]([N:28]3[CH2:27][C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[NH:20][C:19]3=[O:18])[CH2:30][CH2:31]2)=[O:36])[C:3]1=[O:17]

Participants

3

Reactant 2

HCID 183211084-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidine-1-carbonyl chlorideHCID 68562241HCID 68562241, compound

Product 1

HCID 11214031HCID 11214031, compound

Procedure

The title compound was prepared with (3R)-3-amino-1-(3-hydroxybenzyl)azepan-2-one and 4-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidine-1-carbonyl chloride using a similar procedure to Example 16. MS 492.2599 (M+1).

Sources & evidence

ORD record
ord-01a6015a2127478ba9caa281d44310ec
Source dataset
uspto-grants-2007_04
Patent number
US07205292B2

Reaction notes

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