反应详情

10% Palladium on carbon (23 mg) was added to a solution N-{1-benzyl-3-[4-(benzyloxy)benzyl]-2-oxoazepan-3-yl}-4-(2-oxo-1,4-dihydroquinazolin-3 (2H)-yl)piperidine-1-carboxamide (67 mg, 0.100 mmol) in ethanol (5 mL). The reaction vessel was evacuated and back-filled with nitrogen (3×), then back-filled with hydrogen (1 atm). After 32 h, the mixture was filtered and concentrated. Purification by silica gel chromatography (1% methanol/dichloromethane→10% methanol/dichloromethane) gave the title compound (43 mg). MS 582 (M+1).

1. customThe reaction vessel was evacuated
2. additionback-filled with nitrogen (3×)
3. additionback-filled with hydrogen (1 atm)
4. filtrationthe mixture was filtered
5. concentrationconcentrated
6. customPurification by silica gel chromatography (1% methanol/dichloromethane→10% methanol/dichloromethane)