Diethylenetriaminepentaacetic acid → HCID 178419119, compound

Participants

Reaction Conditions

Reaction Steps

A sample of DTPA (1 eq) is added to a solution of acetonitrile (CH3CN, 0.1 M), followed by the addition of triethylamine (NEt3) (5 eq) to provide a cloudy solution that is then degassed for 20 minutes before stirring at 55° C. for 1 hour. The resulting clear colorless solution is then cooled to −45° C., followed by the dropwise addition of isobutylchlorofomate (IBCF) (1.1 eq) and stirring for 1 hour at −45° C., resulting in a white slurry. The slurry is then added to a CH3CN solution of 9-BBN-lysine, 3, (1 eq), and the reaction mixture is stirred at ambient temperature for 12 hours. The volatiles are removed under reduced pressure and the residue recrystallized from THF/diethyl ether (Et2O) to provide the 9-BBN-lysine-DTPA, 4, product as a white solid.

Provenance & Evidence