Sulfuric Acid → HCID 178473868, compound

Participants

Reaction Steps

To a solution of the TFA salt of the single diastereomer (2S,4R)-1-Acetyl-N-[(1S)-1-(2-benzothiazolylcarbonyl)-4-[[imino(amino)methyl]amino]butyl]-4-hydroxypyrrolidine-2-carboxamide (0.30 g, 0.493 mmol) in acetonitrile (4 mL) was added a solution of sulfuric acid (48.3 mg, 0.493 mmol) in acetonitrile (1 mL). A suspension formed upon mixing. The suspension was heated to partially dissolve the solid, then cooled to precipitate the title compound as a solid. The solid was filtered and dried in a vacuum oven at 30° C.

Provenance & Evidence