Dimethylformamide dimethyl acetal → HCID 18454766, compound

Participants

Reaction Steps

A solution of N,N-dimethylformamidedimethylacetal (80 μl, 0.60 mmol) and (6-methyl-2-phenylethynyl-pyridin-3-yl)amine (102 mg, 0.49 mmol) from Example 1, in toluene (1 ml) was heated for 20 h, at 80° C. The solvent was evaporated and the residue was purified by flash chromatography (hexane/ethyl acetate 4:1) to give 24 mg (0.09 mmol, 15%) of N,N-dimethyl-N′-(6-methyl-2-phenylethynyl-pyridin-3-yl)-formamidine as a yellow oil.

Provenance & Evidence