Trimethylsilylacetylene → (6-Methyl-2-trimethylsilanylethynyl-pyridin-3-yl)amine

Participants

Reaction Steps

Following the same procedure as described in Example 1, (2-bromo-6-methyl-pyridin-3-yl)amine (800 mg, 4.28 mmol) reacted with (PPh3)2PdCl2 (150 mg, 0.21 mmol), Cul (41 mg, 0.21 mmol) and ethynyltrimethylsilane (840 mg, 8.55 mmol) in triethylamine (30 ml). The crude residue was purified by flash chromatography (hexane/ethyl acetate 8:2) to yield 330 mg (1.61 mmol, 38%) of (6-methyl-2-trimethylsilanylethynyl-pyridin-3-yl)amine as a beige solid.

Provenance & Evidence