2-Bromo-6-methylpyridin-3-amine → (2-(5-Chloro-pyridin-3-ylethynyl)-6-methyl-pyridin-3-yl)amine

Participants

Reaction Steps

Following the same procedure as described in Example 1, (2-bromo-6-methyl-pyridin-3-yl)amine (150 mg, 0.80 mmol) reacted with (PPh3)2PdCl2 (28 mg, 40 μmol), Cul (8 mg, 40 μmol) and 3-chloro-5-ethynyl-pyridine (165 mg, 1.20 mmol) in triethylamine (5 ml). The crude residue was purified by flash chromatography (hexane/ethyl acetate 7:3) to yield 141 mg (0.58 mmol, 72%) of (2-(5-chloro-pyridin-3-ylethynyl)-6-methyl-pyridin-3-yl)amine as a yellow solid.

Provenance & Evidence