2-Methoxyethylamine → HCID 18454788, compound

Participants

Reaction Conditions

Reaction Steps

Lovastatin (50 gm) is mixed with tetrahydrofuran (100 ml) and methoxy ethylamine (140 ml) to obtain a clear solution, the solution is heated to 50° C. and stirred for 4 hours at the same temperature. Then the solvent is distilled off at reduced pressure not allowing the temperature to raise above 50° C., tetrahydrofuran (200 ml) is added to the residue thus obtained, stirred for 30 minutes and distilled off the solvent to give 58 gm of N-methoxyethyl-7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-[[2(S)-methylbutanoyl]oxy]-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanamide as residue (HPLC Purity 97.3%).

Provenance & Evidence