Methane → Simvastatin

Participants

Reaction Conditions

Reaction Steps

The ammonium salt of step 3 (15 gm) is suspended in toluene (500 ml) and heated at 100° C. under a constant sweep of nitrogen for 5 hours. The solution is cooled to 25° C., activated charcoal (1 gm) is added stirred for 30 minutes and then filtered through celite-bed. The filtrate is concentrated under reduced pressure to a volume of 70 ml. Cyclohexane (200 ml) is added, refluxed for 20 minutes, cooled to 10° C. and stirred for 3 hours at 10° C. The precipitated solid is filtered and washed with cold cyclohexane (100 ml) and dried to obtain simvastatin as white crystalline product. The product is re-crystallized from absolute ethanol to obtain 13 gm of simvastatin (HPLC Purity 99.7%).

Provenance & Evidence