HCID 69418792, compound → HCID 131726337, compound

HRID 1271636Notes

Reaction equation

HRID 1271636 reaction equation
C(OC([N:8]1[CH:12]([CH:13]=[CH:14][C:15]2[CH:16]=[C:17](C)[CH:18]=[CH:19][CH:20]=2)[CH2:11][CH2:10][CH:9]1[C:22]([N:24]1[CH2:28][CH2:27][CH2:26][C@H:25]1[C:29]#[N:30])=[O:23])=O)(C)(C)C.C(OC(N1C(C=CC2C=CC=CC=2)CCC1C(N1CCC[C@H]1C#N)=O)=O)(C)(C)C>>[C:15]1([CH2:14][CH2:13][CH:12]2[NH:8][C@H:9]([C:22]([N:24]3[CH2:28][CH2:27][CH2:26][C@H:25]3[C:29]#[N:30])=[O:23])[CH2:10][CH2:11]2)[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 69418792HCID 69418792, compoundHCID 69418848HCID 69418848, compound

Product 1

HCID 131726337HCID 131726337, compound

Procedure

The title compound was synthesized by substituting 2-(2-(S)-cyano-pyrrolidine-1-carbonyl)-5-(R/S)-(2-m-tolyl-vinyl)-pyrrolidine-1-carboxylic acid tert-butyl ester in Example 36 with 2-(2-(S)-cyano-pyrrolidine-1-carbonyl)-5-(R/S)-(2-phenyl-vinyl)-pyrrolidine-1-carboxylic acid tert-butyl ester. 1H NMR (500 MHz, MeOH-d4) δ 1.83 (m, 1H), 1.99 (m, 2H), 2.26 (m, 6 H), 2.65 (m, 1H), 2.77 (m, 2H), 3.64 (dd, J=7.02, 6.39 Hz, 2H), 3.76 (m, 1H), 4.58 (t, J=8.26 Hz, 1H), 4.83 (dd, J=7.95, 4.52 Hz, 1H), 7.25 (m, 5H) ppm. MS (DCI) m/z 298 (M+H)+.

Sources & evidence

ORD record
ord-3b32cd448de04f1e95faa14191d9b14a
Source dataset
uspto-grants-2007_04
Patent number
US07205409B2

Reaction notes

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