HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1271639Generated: October 30, 2026
Chlorosuccinimide → tert-Butyl 6-chloro-5-hydroxypyridine-3-carboxylate
https://huagongshe.com/reaction/1271639
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | tert-Butyl 5-hydroxypyridine-3-carboxylate | HCID 53432596 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | tert-Butyl 6-chloro-5-hydroxypyridine-3-carboxylate | HCID 53432597 | 50% |
Reaction Steps
The compound of Example 52A (400 mg, 2.05 mmol) was dissolved in DMF (2 mL) and N-chlorosuccinimide (328 mg, 2.46 mmol) was added. The mixture was heated to 80° C. overnight, concentrated and purified by column chromatography to give the chloro pyridine (234 mg, 50%). MS (DCI) m/z 230, 232 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07205409B2 |
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| Source dataset | uspto-grants-2007_04 |
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| ORD ID | ord-886b7ce855844a90a230cf672116d62d |
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| Source note | uspto-grants-2007_04 |
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