HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxybenzoic Acid → 4-Bromo-3-hydroxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxybenzoic Acid | HCID 7420 | — |
| Reactant | Bromine | HCID 24408 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Bromo-3-hydroxybenzoic acid | HCID 6420973 | 40.2% |
Reaction Steps
Bromine (0.37 mL, 7.2 mmol) was added to 3-hydroxybenzoic acid (500 mg, 3.6 mmol) in ethanol (2 mL) and acetic acid (1 mL). The mixture was stirred at room temperature for 30 min and then concentrated and purified by column chromatography to give the product (314 mg, 40%). MS (DCI) m/z 234 (M+NH4)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07205409B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-ae78ae6fd4664bf89df628389830fb92 |
| Source note | uspto-grants-2007_04 |