Hydrochloric Acid → HCID 18454616, compound

Participants

Reaction Steps

4-Methanesulfonylphenol (2.0 g, 11.6 mmol) mixed with 21:14 mL of EtOH:conc HCl was cooled to 0° C., then KClO3 (0.708 g, 5.81 mmol) dissolved in 17 mL of water was added slowly. After reaction overnight, the mixture was extracted with EtOAc and the extracts were concentrated in vacuum. The resulting residue was purified by reverse-phase HPLC to give both 1-chloro-2-methanesulfonyl-4-methoxy-benzene and 2-chloro-1-methanesulfonyl-3-methoxy-benzene. MS (DCI) m/z 224 (M+NH4)+.

Provenance & Evidence