Pyridine → HCID 11453530, compound

HRID 1271647Notes

Reaction equation

HRID 1271647 reaction equation
C(OC([N:8]1[CH:12]([C:13]([N:15]2[CH2:19][CH2:18][CH2:17][CH:16]2[C:20]#[N:21])=[O:14])[CH2:11][CH2:10][CH:9]1[CH2:22][O:23][C:24]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[C:27]([NH2:34])=[CH:26][CH:25]=1)=O)(C)(C)C.N1C=CC=CC=1.[CH3:41][S:42](Cl)(=[O:44])=[O:43]>C(Cl)Cl>[C:20]([C@@H:16]1[CH2:17][CH2:18][CH2:19][N:15]1[C:13]([C@H:12]1[NH:8][C@@H:9]([CH2:22][O:23][C:24]2[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[C:27]([NH:34][S:42]([CH3:41])(=[O:44])=[O:43])=[CH:26][CH:25]=2)[CH2:10][CH2:11]1)=[O:14])#[N:21]

Participants

5

Reactant 3

HCID 1049PyridineHCID 31297Methanesulfonyl chlorideHCID 69421484HCID 69421484, compound

Product 1

HCID 11453530HCID 11453530, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound of Example 97A (32 mg, 0.07 mmol) was dissolved in CH2Cl2 (1 mL) and pyridine (0.5 mL) in a microwave reaction tube. Methanesulfonyl chloride (6.0 μL, 0.21 mmol) was added. It was reacted under microwave condition at 130° C. for 20 minutes. The mixture was filtered and purified by reverse phase HPLC to give the desired sulfonamide.

Workup

  1. customIt was reacted under microwave condition at 130° C. for 20 minutes
  2. filtrationThe mixture was filtered
  3. custompurified by reverse phase HPLC

Sources & evidence

ORD record
ord-d1e24789233a43e5bb422fe03de0be03
Source dataset
uspto-grants-2007_04
Patent number
US07205409B2

Reaction notes

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