Alanine methyl ester hydrochloride → HCID 87830865, compound

Participants

Reaction Steps

L-Ala-OMe HCl salt (1.00 g, 7.16 mmol) was suspended in methyl acetate (15 ml), and benzenesulfonic acid monohydrate (BsOH H2O) (1.51 g, 8.57 mmol) was added. The mixture was stirred for dissolution. This solution was concentrated under reduced pressure, and methyl acetate (15 ml) was added. The mixture was concentrated twice under reduced pressure, and the obtained concentrate was cooled in a refrigerator. Since partial crystallization occurred, diethyl ether (3 ml) and methyl acetate (15 ml) were added to dissolve the crystals almost entirely at 40° C. This solution was stirred at room temperature and cooled overnight in a refrigerator. The crystals were separated and dried to give L-alanine methyl ester benzenesulfonate (L-Ala-OMe BsOH salt) crystals. The crystals were left standing at room temperature for a while. As a result, the crystals were liquefied and failed to provide stable crystals.

Provenance & Evidence