Hydrochloric Acid → HCID 18454846, compound

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Reaction Steps

A solution of 0.125 g (0.36 mM) of the ester obtained in step 1 in 0.364 ml of 1 N sodium hydroxide is cooled to 0° C. 0.05 g (1.2 eq) of potassium thioacetate is added and the mixture is stirred at room temperature for 48 hours. The resulting mixture is acidified to 0° C. with 1N hydrochloric acid solution. It is extracted with ethyl acetate and the organic phase is washed with water and with saturated sodium chloride solution. After drying and evaporation, a colorless oil is obtained. (Mass: 0.12 g, 98%). Rf (c.Hex/EtOAc/AcOH: 7/3/0.5)=0.11.

Provenance & Evidence