Hexamethylenetetramine → 3-Methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-carbaldehyde

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Reaction Steps

3-Methyl-3H-benzoxazol-2-one (2.0 g, 13.4 mmol) and hexamethylenetetramine (3.7 g, 26.8 mmol) were dissolved in trifluoroacetic acid (20 ml) and heated at reflux for 20 hours. The volatiles were removed in vacuo and the residue was treated with ice water (60 ml). The resultant mixture was stirred for 30 minutes and then basified with sodium carbonate. The solid was isolated by filtration, washed with water and then dried under vacuum. The solid was purified by column chromatography on silica gel eluting with an ethyl acetate and hexane solvent gradient. This provided the aldehyde as a white solid (1.07 g, 45%).

Provenance & Evidence