Hydrazine → HCID 22131447, compound

HRID 1271781Notes

Reaction equation

HRID 1271781 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][N:13]1C(=O)C2=CC=CC=C2C1=O.NN>CCO>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][NH2:13]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 22131444HCID 22131444, compound

Product 1

HCID 22131447HCID 22131447, compoundYield 103.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-(2-quinolyl)methoxy phthalimide (1.53 g) was suspended in 95% EtOH and hydrazine (0.30 mL) was added. The reaction mixture was stirred for 5 h and then filtered. The filtrate was concentrated under reduced pressure and then taken up in a small amount of dichloromethane. The small amount of remaining phthalhydrazide was then removed by filtration. The filtrate was concentrated under reduced pressure to give the title compound (0.91 g) as a yellow oil. MS(CI) m/e 175 (M+H)+.

Workup

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated under reduced pressure
  3. customThe small amount of remaining phthalhydrazide was then removed by filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-1d0b3f0c5cf142468b3c5b89cbaed730
Source dataset
uspto-grants-2007_04
Patent number
USRE039591E1

Reaction notes

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