反应详情

A solution of 4-hydroxymethyl-5-methylimidazole hydrochloride (30 g) and cysteamine hydrochloride (23 g) in acetic acid (200 ml) was heated under reflux for 10 hours. Following cooling to 15°-20° C., the solid which crystallised was collected and washed with isopropyl alcohol to give 2[(5-methylimidazol-4-yl)methyl]thioethylamine dihydrochloride (45.5 g), m.p. 189°-192° C.

1. temperatureunder reflux for 10 hours
2. temperatureFollowing cooling to 15°-20° C.
3. customthe solid which crystallised
4. customwas collected
5. washwashed with isopropyl alcohol