Water → HCID 18454871, compound

HRID 1271807Notes

Reaction equation

HRID 1271807 reaction equation
C([N:8](CC1C=CC=CC=1)[CH2:9][CH:10]([OH:48])[CH2:11][N:12]1[CH2:23][CH2:22][N:21]([CH2:24][C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:20][CH2:19][N:18]([CH2:32][C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:17][CH2:16][N:15]([CH2:40][C:41]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42])[CH2:14][CH2:13]1)C1C=CC=CC=1.O>CO.[Pd]>[NH2:8][CH2:9][CH:10]([OH:48])[CH2:11][N:12]1[CH2:23][CH2:22][N:21]([CH2:24][C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:20][CH2:19][N:18]([CH2:32][C:33]([O:35][C:36]([CH3:37])([CH3:38])[CH3:39])=[O:34])[CH2:17][CH2:16][N:15]([CH2:40][C:41]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42])[CH2:14][CH2:13]1

Participants

5

Reactant 2

HCID 962WaterHCID 18454873HCID 18454873, compound

Product 1

HCID 18454871HCID 18454871, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

76.8 g (100 mmol) of 10-(3-dibenzylamino-2-hydroxypropyl)-1,4,7-tris-(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane is dissolved in 500 ml of methanol, mixed with 40 ml of water, and 10 g of palladium catalyst (20% Pd/C) is added. It is hydrogenated for 8 hours at 50° C. under normal pressure. Catalyst is filtered out, and the filtrate is evaporated to the dry state in a vacuum.

Workup

  1. additionis added
  2. filtrationCatalyst is filtered out
  3. customthe filtrate is evaporated to the dry state in a vacuum

Sources & evidence

ORD record
ord-2257620e40e549748098a87cd8c2007a
Source dataset
uspto-grants-2007_04
Patent number
US07208140B2

Reaction notes

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