関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Vanillin | HCID 1183 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 5-(2-Methanesulfonyl-ethyl)-4-methyl-thiazole | HCID 18455442 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 18455223 | HCID 18455223 | — |
反応手順
Vanillin (2.9 mmol) was added to mixture of K2CO3 (14.5 mmol) and 5-(2-Methanesulfonyl-ethyl)-4-methyl-thiazole (5) (2.9 mmol) in DMF (0.2 M), and heated to 75° C. for 16 h. After cooling, water was added and aqueous mixture extracted 5 times with methylene chloride. The methylene chloride layers were combined and concentrated to afford the product (6).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07208488B2 |
|---|
| 出典データセット | uspto-grants-2007_04 |
|---|
| ORD ID | ord-dc70c4ccd5a04b8b877b78c92cd10a50 |
|---|
| 出典メモ | uspto-grants-2007_04 |
|---|
