tert-butyl N-(2-oxoethyl)carbamate → HCID 9932869, compound

Participants

Reaction Steps

Preparation of {2-[1-(3-Benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-2-methyl-propylamino]-ethyl}-carbamic acid tert-butyl ester: Sodium triacetoxyborohydride (172 mg, 0.81 mmol) was added to a solution containing 2-(1-amino-2-methyl-propyl)-3-benzyl-7-chloro-3H-quinazolin-4-one (185 mg, 0.54 mmol) (prepared using the general procedure described in WO 0130768) and tert-butyl N-(2-oxoethyl)carbamate (103 mg, 0.65 mmol) in CH2Cl2 (5.4 mL). The resulting mixture was stirred at room temperature overnight. The reaction was diluted with CH2Cl2 (10 mL), washed with brine, dried and concentrated under vacuum. Purification by flash chromatography on silica gel (5–10% EtOAc in hexane) gave the title compound (105 mg) as a white solid: MS (ES) m/e 485 (M+H)+.

Provenance & Evidence