Triethylamine → HCID 9932869, compound

Participants

Reaction Steps

(2-{Acryloyl-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-2-methyl-propyl]-amino}-ethyl)-carbamic acid tert-butyl ester: Acryloyl chloride (126 μL, 1.6 mmol) was added to {2-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-2-methyl-propylamino]-ethyl}-carbamic acid tert-butyl ester (500 mg, 1.03 mmol) and Et3N (216 μL, 0.15 mmol) in CH2Cl2 (10 mL). The resulting mixture was stirred at room temperature overnight. The reaction mixture was diluted with CH2Cl2 (10 mL), washed with brine, dried and concentrated under vacuum. Purification by flash chromatography on silica gel (10% EtOAc/hexane) gave the title compound (310 mg) as a white solid: MS (ES) m/e 539.2 (M+H)+.

Provenance & Evidence