HCID 69474953, compound → HCID 69471534, compound

HRID 1271880Notes

Reaction equation

C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]([C:34](=[O:37])[CH:35]=[CH2:36])[C@@H:11]([C:15]1[N:24]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:23](=[O:32])[C:22]2[C:17](=[CH:18][C:19]([Cl:33])=[CH:20][CH:21]=2)[N:16]=1)[CH:12]([CH3:14])[CH3:13])(C)(C)C.C(OC(=O)NCCN[C@@H](C1N(CC2C=CC=CC=2)C(=O)C2C(=CC(Cl)=CC=2)N=1)C(C)C)(C)(C)C>>[CH2:25]([N:24]1[C:23](=[O:32])[C:22]2[C:17](=[CH:18][C:19]([Cl:33])=[CH:20][CH:21]=2)[N:16]=[C:15]1[C@H:11]([N:10]1[C:34](=[O:37])[CH2:35][CH2:36][NH:7][CH2:8][CH2:9]1)[CH:12]([CH3:13])[CH3:14])[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

Reactant 2

HCID 69474953HCID 69474953, compound

HCID 69474960HCID 69474960, compound

Product 1

HCID 69471534HCID 69471534, compound

Procedure

(2-{Acryloyl-[(R)-1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-2-methyl-propyl]-amino}-ethyl)-carbamic acid tert-butyl ester: According to the procedure of Example 1c above, {2-[(R)1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-2-methyl-propylamino]-ethyl}-carbamic acid tert-butyl ester (211 mg, 0.44 mmol) was converted to the title compound as a white solid: MS (ES) m/e 539.2 (M+H)+.

Sources & evidence

ORD record: ord-a543c5d6700e4973883520346f7079cc
Source dataset: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07208487B2

Reaction notes

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