Benzyl Bromide → HCID 10256409, compound

Participants

Reaction Steps

3-Benzyl-7-chloro-2-[2-methyl-1-(7-oxo-[1 ,4]diazepan-1-yl)-propyl]-3H-quinazolin-4-one from Example 1e above, (133 mg, 0.30 mmol) was treated with benzyl bromide and Et3N in CH2Cl2 (10 mL) at room temperature overnight. The mixture was diluted with CH2Cl2 (10 mL), washed with H2, brine, dried and concentrated under vacuum. Purification by flash chromatography on silica gel (20% EtOAc/hexane) gave the title compound as a white solid: MS (ES) m/e 529.0 (M+H)+.

Provenance & Evidence