tert-Butyl carbamate → HCID 10048021, compound

HRID 1271885Notes

Reaction equation

HRID 1271885 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]([C:33](=[O:36])[CH:34]=[CH2:35])[CH:11]([C:14]1[N:23]([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:22](=[O:31])[C:21]2[C:16](=[CH:17][C:18]([Cl:32])=[CH:19][CH:20]=2)[N:15]=1)[CH2:12][CH3:13])(C)(C)C.C(OC(=O)N)(C)(C)C>>[CH2:24]([N:23]1[C:22](=[O:31])[C:21]2[C:16](=[CH:17][C:18]([Cl:32])=[CH:19][CH:20]=2)[N:15]=[C:14]1[CH:11]([N:10]1[C:33](=[O:36])[CH2:34][CH2:35][NH:7][CH2:8][CH2:9]1)[CH2:12][CH3:13])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 69475326HCID 69475326, compound

Product 1

HCID 10048021HCID 10048021, compound

Procedure

Preparation of (2-{acryloyl-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-propyl]-amino}-ethyl)-carbamic acid tert-butyl ester: Following the procedure of Example of 1c, 2-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-propylamino]-ethyl}-carbamic acid tert-butyl ester (940 mg, 2 mmol) was converted to the title compound as a white solid: MS (ES) m/e 525.4 (M+H)+.

Sources & evidence

ORD record
ord-9870fefa3f554e7e8e8a056330b0cc75
Source dataset
uspto-grants-2007_04
Patent number
US07208487B2

Reaction notes

Loading…