tert-Butyl carbamate → HCID 10048021, compound

HRID 1271886Notes

Reaction equation

HRID 1271886 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]([CH:9]([C:12]1[N:21]([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:20](=[O:29])[C:19]2[C:14](=[CH:15][C:16]([Cl:30])=[CH:17][CH:18]=2)[N:13]=1)[CH2:10][CH3:11])[C:5](=[O:8])[CH:6]=[CH2:7].C(OC(=O)N)(C)(C)C>>[CH2:22]([N:21]1[C:20](=[O:29])[C:19]2[C:14](=[CH:15][C:16]([Cl:30])=[CH:17][CH:18]=2)[N:13]=[C:12]1[CH:9]([N:4]1[C:5](=[O:8])[CH2:6][CH2:7][NH:1][CH2:2][CH2:3]1)[CH2:10][CH3:11])[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 18455034HCID 18455034, compound

Product 1

HCID 10048021HCID 10048021, compound

Procedure

Preparation of N-(2-amino-ethyl)—N-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-propyl]-acrylamide: Following the procedure of Example of 1d, 2-{acryloyl-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-propyl]-amino}-ethyl)-carbamic acid tert-butyl ester was converted to the title compound as a white solid: MS (ES) m/e 425.4 (M+H)+.

Sources & evidence

ORD record
ord-d2f3a7cb973944e59cdcee1a4b166848
Source dataset
uspto-grants-2007_04
Patent number
US07208487B2

Reaction notes

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