Triethylamine → HCID 10457279, compound

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Reaction Steps

Preparation of {2-[[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-2-methyl-propyl]-(3-chloro-2,2-dimethyl-propanoyl)-amino]-ethyl}-carbamic acid tert-butyl ester: {2-[1-(3-Benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-2-methyl-propylamino]-ethyl}-carbamic tert-butyl ester (450 mg, 0.93 mmol) was treated with 3-chloropivaloyl chloride (360 μL, 2.80 mmol) and Et3N (388 μl, 2.80 mmol) in CH2Cl2 (10 mL) at room temperature. After 48 h, the mixture was diluted with CH2Cl2 (10 mL), washed with water, brine, dried and concentrated under vacuum. Purification by flash chromatography on silica gel (3–6% EtOAc in hexane) gave the title compound (413 mg) as a clear oil: MS (ES) m/e 603 (M+H)+.

Provenance & Evidence