tert-Butyl carbamate → HCID 10457279, compound

HRID 1271889Notes

Reaction equation

HRID 1271889 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]([CH:12]([C:16]1[N:25]([CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:24](=[O:33])[C:23]2[C:18](=[CH:19][C:20]([Cl:34])=[CH:21][CH:22]=2)[N:17]=1)[CH:13]([CH3:15])[CH3:14])[C:5](=[O:11])[C:6]([CH3:10])([CH3:9])[CH2:7]Cl.C(OC(=O)N)(C)(C)C>>[CH2:26]([N:25]1[C:24](=[O:33])[C:23]2[C:18](=[CH:19][C:20]([Cl:34])=[CH:21][CH:22]=2)[N:17]=[C:16]1[CH:12]([N:4]1[C:5](=[O:11])[C:6]([CH3:7])([CH3:9])[CH2:10][NH:1][CH2:2][CH2:3]1)[CH:13]([CH3:15])[CH3:14])[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 18455032HCID 18455032, compound

Product 1

HCID 10457279HCID 10457279, compound

Procedure

Preparation of N-(2-amino-ethyl)-N-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-2-methyl-propyl]-3-chloro-2,2-dimethyl-propionamide: Following the procedure of Example 1d, 2-[[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-2-methyl-propyl]-(3-chloro-2,2-dimethyl-propanoyl)-amino]-ethyl}carbamic acid tert-butyl ester was converted to the title compound as a white solid: MS (ES) m/e 503.2 (M+H)+.

Sources & evidence

ORD record
ord-0de9a5d6dfaf4f96b432d454384b2d5e
Source dataset
uspto-grants-2007_04
Patent number
US07208487B2

Reaction notes

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