HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 1',3,3'-Trimethyl-2,3,4,4a-tetrahydro-1H,2'H,6H-spiro[pyrazino[1,2-a]quinoline-5,5'-pyrimidine]-2',4',6'(1'H,3'H)-trione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | o-Fluorobenzaldehyde | HCID 67970 | — |
| Reactant | Dimethylbarbituric acid | HCID 69860 | — |
| Product | 1',3,3'-Trimethyl-2,3,4,4a-tetrahydro-1H,2'H,6H-spiro[pyrazino[1,2-a]quinoline-5,5'-pyrimidine]-2',4',6'(1'H,3'H)-trione | HCID 3430687 | 55% |
Reaction Steps
In a manner similar to that described in Example 1, except starting with 2-fluorobenzaldehyde, 1-methylpiperazine and 1,3-dimethylbarbituric acid, 190 mg (55%) of the title compound is obtained. 1H NMR (400 MHz, CDCl3) δ 7.19, 7.04, 6.95, 6.80, 3.98, 3.62, 3.55, 3.39, 3.32, 3.10, 3.04, 2.82, 2.57, 2.23, 2.21, 1.86.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07208490B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-c97ea29f05d54aa19613e8b87e7c0207 |
| Source note | uspto-grants-2007_04 |