Barbituric Acid → HCID 7298503, compound

Participants

Reaction Conditions

Reaction Steps

2-[(2S,6S)-2,6-Dimethylmorpholin-4-yl]-5-nitrobenzaldehyde (298 mg, 1.12 mmol) is combined with barbituric acid (159 mg, 1.12 mmol, Aldrich) in a vial with MeOH (2 mL). The sealed reaction is heated to 60° C. on a shaker block for 21 hours and then the solvent is evaporated. The product is purified on a Biotage Flash 40M+ using a 1:1 mixture of EtOAc and toluene as eluent Product is dried under vacuum yielding a yellow-orange solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.91, 1.24, 2.91, 3.56, 3.63, 3.83–3.91, 3.95, 4.07, 4.14–4.24, 6.85, 7.83, 7.98, 11.59, 11.89.

Provenance & Evidence