2,6-Xylyl isocyanate → HCID 18456131, compound

Participants

Reaction Steps

A solution of 1-(4-aminopiperidyl)-3-(2-methoxyphenoxy)propan-2-ol (40 mg) and 2,6-dimethylphenylisocyanate (30 μl) in dichloromethane (1 ml) was refluxed for 2 hours, after which time a further 20 μl of 2,6-dimethylphenylisocyanate was added, and the mixture refluxed for a further 2 hours. Solvent was removed under reduced pressure, and the residue flash chromatographed (0–6% methanol/dichloromethane), to provide [(2,6-dimethylphenyl)amino]-N-{1-[2-hydroxy-3-(2-methoxyphenoxy)propyl](4-piperidyl)}carboxamide.

Provenance & Evidence